The sign shows three small businesses; Payless Shoes, Radio Shack, and HFC/Household Finance Corporation. I have no idea when HFC closed down operations (the small empty shop on the left of Radio Shack) but the weathering is pretty extensive now, indicating some four to five years ago. The closing of Playless is more recent.
This isn't to say that the whole area is dying. The K-Mart is still in business, and across the parking lot is an Olive Garden that's been in business as long as we've been living in Orlando, since 1985. And then there's Florida Mall itself across the street. But the smaller businesses are showing far more stress than the bigger businesses (with the odd exception of chains such as Circuit City). And those small empty businesses are all around.
bleaching pile of cinderblock I discovered this past Easter on the other side of I-4, near where they're building the new bridge over I-4, linking International Drive and Palm Parkway just a mile further up the road.